Machine Learning with Constraints and Priors: A Geometric View on Scientific AI

Machine Learning has become a powerful tool for modeling complex systems, yet many scientific and engineering applications remain challenging due to limited data, physical constraints, and the need for reliable predictions. In such settings, learning from data alone is often insufficient. Instead, machine learning models must leverage prior knowledge, including physical laws, structural constraints, symmetries, and invariances. In this presentation, we explore how geometry provides a unifying framework for incorporating constraints and priors into machine learning. Through the lens of geometric learning, seemingly different approaches—including constrained optimization, manifold learning, and physics-informed models—can be viewed as ways of restricting learning to scientifically meaningful solutions. Using examples from biomedical and scientific data analysis, we illustrate how geometry-aware representations can improve robustness, data efficiency, and interpretability. More broadly, the talk advocates for a vision of Scientific AI in which learning is guided not only by data, but also by the wealth of knowledge accumulated through scientific understanding.

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